長崎大学　高度感染症研究センター
ウイルス感染動態研究分野

研究業績 (2017年以降)

原著論文

  1. Saito T, Miyamoto H, Igarashi M, Nanbo A, Hayashi R, Paroha R, Siman-Tov G, Littlefield K, Mori-Kajihara A, Click C, Furuyama W, Paessler S, Maruyama J, Takada A. Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential. Npj Viruses, 3:84, 2025
  2. Furuyama W, Sakaguchi M, Ariyoshi H, Nanbo A. Development of a Novel, Highly Sensitive System for Evaluating Ebola Virus Particle Formation. Viruses, 17, 2025
  3. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Wang Y, Miyanaga K, Cui L, Fernandez S, Huang AT, Melhem NM, Singer AC, Ragupathi NKD, Calabria de Araujo J, Sei K, Ndatuwong LG, Mahmood SF, Shimotai Y, Kanjanabuch T, Higgins PG, Aoyagi T, Kicic A, Nanbo A, Mori H, Siow R, Kurt Ö, Trowsdale S, Hongsing P, Khatib A, Sano D, Shibuya K, Abe S, Hamamoto H. Global participatory wastewater surveillance to understand mpox clade diversity in war and conflict-affected countries. J Travel Med, 32, 2025
  4. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Besa JJV, Miyanaga K, Cui L, Fernandez S, Huang AT, Ounjai P, Werawatte W, Rad SMA, Vatanaprasan P, Jay DJ, Saethang T, Luk-In S, Kanthawee P, Thuptimdang W, Tacharoenmuang R, Cynthia B, Vitharana S, Ngamwongsatit N, Ishikawa H, Furukawa T, Wang Y, Singer AC, Ragupathi NKD, Chatsuwan T, Sei K, Nanbo A, Leelahavanichkul A, Kanjanabuch T, Hamamoto H, Higgins PG, Sano D, Kicic A, Valdebenito JO, Bonnedahl J, Trowsdale S, Hongsing P, Khatib A, Shibuya K, Abe S. Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics. Nat Commun, 16:4900, 2025
  5. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Besa JJV, Miyanaga K, Cui L, Fernandez S, Huang AT, Ounjai P; Pathogen Hunters Research Team; Singer AC, Ragupathi NKD, Furukawa T, Sei K, Nanbo A, Leelahavanichkul A, Kanjanabuch T, Chatsuwan T, Higgins PG, Sano D, Kicic A, Rockstroh JK, Siow R, Trowsdale S, Hongsing P, Khatib A, Shibuya K, Abe S. Community-based mpox and sexually transmitted disease surveillance using discarded condoms in the global south. Lancet Infect Dis., 24(10):e610-e613, 2024
  6. Furuyama W, Yamada K, Sakaguchi M, Marzi A, Nanbo A. Marburg virus exploits the Rab11-mediated endocytic pathway in viral-particle production. Microbiol Spectr., e0026924. 2024
  7. Sasaki D, Arai T, Yang Y, Kuramochi M, Furuyama W, Nanbo A, Sekiguchi H, Morone N, Mio K, Sasaki YC. Micro-second time-resolved X-ray single-molecule internal motions of SARS-CoV-2 spike variants. Biochem Biophys Rep., 29;38:101712, 2024
  8. Ashida S, Kojima S, Okura T, Kato F, Furuyama W, Urata S, Matsumoto Y. Phylogenetic analysis of the promoter element 2 of paramyxo- and filoviruses. Microbiol Spectr., 12(5):e0041724, 2024
  9. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Chadsuthi S, Anupong S, Miyanaga K, Cui L, Fernandez S, Huang AT, Ounjai P, Singer AC, Ragupathi NKD, Sano D, Furukawa T, Sei K, Leelahavanichkul A, Kanjanabuch T, Chatsuwan T, Higgins PG, Nanbo A, Kicic A, Siow R, Trowsdale S, Hongsing P, Khatib A, Shibuya K, Abe S, Ishikawa H. Pathogen Hunters Research Team. Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1. Lancet Infect Dis., 24(6):e348-e350, 2024
  10. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Chadsuthi S, Anupong S, Miyanaga K, Cui L, Werawatte WKCP, Ali Hosseini Rad SM, Fernandez S, Huang AT, Vatanaprasan P, Saethang T, Luk-In S, Storer RJ, Ounjai P, Tacharoenmuang R, Ragupathi NKD, Kanthawee P, Cynthia B, Besa JJV, Leelahavanichkul A, Kanjanabuch T, Higgins PG, Nanbo A, Kicic A, Singer AC, Chatsuwan T, Trowsdale S, Furukawa T, Sei K, Sano D, Ishikawa H, Shibuya K, Khatib A, Abe S, Hongsing P. Wastewater-based epidemiological surveillance of SARS-CoV-2 new variants BA.2.86 and offspring JN.1 in South and Southeast Asia. J Travel Med., 31(4):taae040, 2024
  11. Anupong S, Chadsuthi S, Hongsing P, Hurst C, Phattharapornjaroen P, Rad S M AH, Fernandez S, Huang AT, Vatanaprasan P, Saethang T, Luk-In S, Storer RJ, Ounjai P, Devanga Ragupathi NK, Kanthawee P, Ngamwongsatit N, Badavath VN, Thuptimdang W, Leelahavanichkul A, Kanjanabuch T, Miyanaga K, Cui L, Nanbo A, Shibuya K, Kupwiwat R, Sano D, Furukawa T, Sei K, Higgins PG, Kicic A, Singer AC, Chatsuwan T, Trowsdale S, Abe S, Ishikawa H, Amarasiri M, Modchang C, Wannigama DL. Exploring indoor and outdoor dust as a potential tool for detection and monitoring of COVID-19 transmission. iScience., 26;27(3):109043, doi: 10.1016/j.isci.2024. 2024
  12. Dochi H, Kondo S, Komura S, Moriyama-Kita M, Komori T, Nanbo A, Sakaguchi M, Fukuyo M, Hamabe-Horiike T, Tanaka M, Mizokami H, Kano M, Kitagawa Y, Kobayashi E, Hirai N, Ueno T, Nakanishi Y, Endo K, Sugimoto H, Hanayama R, Kaneda A, Yoshizaki T. Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein-Barr virus: A poor prognostic marker. Int J Cancer., 1;154(5):895-911, doi: 10.1002/ijc.34777. 2024
  13. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Chadsuthi S, Anupong S, Miyanaga K, Cui L, Fernandez S, Huang AT, Ounjai P, Tacharoenmuang R, Ragupathi NKD, Sano D, Furukawa T, Sei K, Leelahavanichkul A, Kanjanabuch T, Higgins PG, Nanbo A, Kicic A, Singer AC, Chatsuwan T, Trowsdale S, Khatib A, Shibuya K, Abe S, Ishikawa H, Hongsing P. Pathogen Hunters Research Team. Tracing the new SARS-CoV-2 variant BA.2.86 in the community through wastewater surveillance in Bangkok, Thailand. Lancet Infect Dis., 23(11):e464-e466. doi: 10.1016/S1473-3099(23)00620-5, 2024
  14. Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Chadsuthi S, Anupong S, Miyanaga K, Cui L, Thuptimdang W, Ali Hosseini Rad SM, Fernandez S, Huang AT, Vatanaprasan P, Jay DJ, Saethang T, Luk-In S, Storer RJ, Ounjai P, Ragupathi NKD, Kanthawee P, Sano D, Furukawa T, Sei K, Leelahavanichkul A, Kanjanabuch T, Higgins PG, Nanbo A, Kicic A, Singer AC, Chatsuwan T, Trowsdale S, Siow R, Shibuya K, Abe S, Ishikawa H, Hongsing P. Tracing the transmission of mpox through wastewater surveillance in Southeast Asia. J Travel Med., 5;30(5):taad096. doi: 10.1093/jtm/taad096. 2023
  15. Satoh AO, Fujioka Y, Kashiwagi S, Yoshida A,; Fujioka M, Sasajima H, Nanbo A, Amano M, Ohba Y. Interaction Between PI3K and the VDAC2 Channel Tethers Ras-PI3K-positive Endosomes to Mitochondria and Promotes Endosome Maturation, Cell Reports, 28;42(3):112229. doi: 10.1016/j.celrep.2023.112229. 2023
  16. Furuyama W, Sakaguchi M, Yamada K, Nanbo A. Development of an imaging system for visualization of Ebola virus glycoprotein throughout the viral lifecycle. Front Microbiol., 3;13:1026644, 2022
  17. Dochi H, Kondo S, Murata T, Fukuyo M, Nanbo A, Wakae K, Jiang WP, Hamabe-Horiike T, Tanaka M, Nishiuchi T, Mizokami H, Moriyama-Kita M, Kobayashi E, Hirai N, Komori T, Ueno T, Nakanishi Y, Hatano M, Endo K, Sugimoto H, Wakisaka N, Juang SH, Muramatsu M, Kaneda A, Yoshizaki T. Estrogen induces the expression of EBV lytic protein ZEBRA, a marker of poor prognosis in nasopharyngeal carcinoma, Cancer Sci., 113(8):2862-2877, 2022
  18. Yamaki K, Ohta K, Kobayashi N, Morita I, Kiguchi Y, Oyama H, Ito K, Nanbo A, Oh-Oka H, Koyama Y, Kawata Y, Fujisawa H, Ohta M. Purification of Emu IgY for Therapeutic and Diagnostic Use Based on Monoclonal Secondary Antibodies Specific to Emu IgY, Biol Pharm Bull, 45(8):1022-1026, 2022
  19. Isono M, Furuyama W, Kuroda M, Kondoh T, Igarashi M, Kajihara M, Yoshida R, Manzoor R, Okuya K, Miyamoto H, Feldmann H, Marzi A, Sakaitani M, Nanbo A, Takada A. A biaryl sulfonamide derivative as a novel inhibitor of filovirus infection, Antivir Res, 183:104932, 2020.
  20. Zhao M, Nanbo A, Becnel D, Qin Z, Morris G, Li L, Lin Z. Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta, J Virol, 94(22):e01298-20, 2020
  21. Furuyama W, Nanbo A, Maruyama J, Marzi A, Takada A. A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection, PLoS Negl Trop Dis, 14(9):e0008602, 2020
  22. Nanbo A. Epstein-Barr Virus Exploits the Secretory Pathway to Release Virions, Microorganisms. 8(5):729, 2020
  23. Kheir F, Zhao M, Strong MJ, Yu Y, Nanbo A, Flemington EK, Morris GF, Reiss K, Li L, Lin Z. Detection of Epstein-Barr Virus Infection in Non-Small Cell Lung Cancer. Cancers 1. pii: E759, 2019
  24. Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, Ohba Y. A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection. Cell Struct Funct, 44:61-74, 2019
  25. Nanbo A, Ohba Y. Budding of Ebola virus particles requires the Rab11-dependent endocytic recycling pathway. J Infect Dis, 218. suppl_5 S388 S396, 2018
  26. Nanbo A, Katano H, Kataoka M, Hoshina S, Sekizuka T, Kuroda M, Ohba Y. Infection of Epstein–Barr Virus in Type III Latency Modulates Biogenesis of Exosomes and the Expression Profile of Exosomal miRNAs in the Burkitt Lymphoma Mutu Cell Lines. Cancers, 10(7). pii: E237, 2018
  27. Fujioka Y, Nishide S, Ose T, Kato U, Fukuhara H, Fujioka M, Horiuchi K, Satoh AO, Nepal P, Kashiwagi S，Wang J, Horiguchi M, Paudel S, Nanbo A, Miyazaki T, Maenaka K, Ohba Y. Influenza A Virus Entry into Mammalian Cells Requires A Voltage-Dependent Ca2+ Channel. Cell Host Microbe, 23(6): 809-818.e5, 2018
  28. Nanbo A, Ohashi M, Yoshiyama H, Ohba Y. The role of tumor growth factor β in cell-to-cell contact-mediated Epstein-Barr virus transmission. Front Microbio, 9, 984, 2018
  29. Nanbo A, Noda T, Ohba Y. Epstein–Barr Virus Acquires Its Final Envelope on Intracellular Compartments With Golgi Markers, Front Microbiol, 9, 454, 2018
  30. Nanbo A, Maruyama J, Imai M, Ujie M, Fujioka Y, Nishide S, Takada A, Ohba Y, Kawaoka Y. Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles, PLoS Pathog, 14(1):e1006848. 2018

総説

  1. 南保明日香. 長崎大学BSL-4施設使用のための教育訓練プログラムの開発 日本臨床検査医学会誌, 72(6),482-485, 2024
  2. Nanbo A. Current Insights into the Maturation of Epstein-Barr Virus Particles.Microorganisms., 12(4):806, 2024
  3. 古山若呼, 南保明日香. 海外BSL-4施設紹介 2022年12月、ウイルス, 72(2), p139-148
  4. 南保明日香, 浦田秀造, 津田祥美. 長崎大学BSL-4施設使用にかかる教育訓練プログラム開発への取り組み 2022年12月、ウイルス, 72(2), p125-130
  5. 南保明日香. 長崎市医師会報生涯教育シリーズ、エボラウイルス病と治療法開発の現状について 2022年5月号、p15-21
  6. Becnel D, Abdelghani R, Nanbo A, Avilala J, Kahn J, Li L, Lin Z. Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses., 13(5):877. 2021.
  7. Nanbo A, Furuyama W, Lin Z. RNA Virus-Encoded miRNAs: Current Insights and Future Challenges. Front Microbiol., 24 (12):679210. 2021
  8. Avilala J, Becnel D, Abdelghani R, Nanbo A, Kahn J, Li L, Lin Z. Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses. Front Microbiol. 12:657036. 2021.
  9. 南保明日香. エボラウイルス粒子へのホスファチジルセリン集積の分子機構の解明, Journal of the Society of Japanese Women Scientists, 2020 年 20 巻 1 号 p1-8
  10. Nanbo A, Kawaoka Y. Molecular Mechanism of Externalization of Phosphatidylserine on the Surface of Ebola Virus Particles. DNA Cell Biol., 38(2), 115-120, 2019
  11. Zhao M, Nanbo A, Sun L, Lin Z. Extracellular Vesicles in Epstein-Barr Virus' Life Cycle and Pathogenesis. Microorganisms., 7(2). pii: E48, 2019
  12. Kolesnikova L, Nanbo A, Kawaoka Y, Becker S. Inside the Cell. Curr Top Microbiol Immunol., 411:353-380, 2017

書籍

  1. Furuyama W, Nanbo A.. Quantification of Filovirus Soluble Glycoprotein Using a Sandwich ELISA. Methods Mol Biol. 2025;2877:409-419. doi: 10.1007/978-1-0716-4256-6_28. 2025
  2. Nanbo A, Sakaguchi M, Furuyama W. Visualizing the Internalization of Marburg Viruslike Particles into Living Cells. Methods Mol Biol. 2025;2877:75-90. doi: 10.1007/978-1-0716-4256-6_6. 2025
  3. 南保明日香. EBウイルスによるBリンパ球不死化機構(改訂第2版)，p90-94（柳井秀雄編：EBウイルス関連胃癌 ，診断と治療社出版，東京），2022
  4. 南保明日香. エボラウイルス侵入のプロセス, 創薬研究者が押さえておくべきウイルス学（技術情報協会）, 2021