長崎大学高度感染症研究センター ウイルス制御研究分野/BSL-4人材育成部門 浦田研究室
長崎大学
English

研究業績 (*corresponding author)

  1. Ashida S., Kojima S., Okura T., Kato F., Furuyama W., Urata S., Matsumoto Y., Phylogenetic analysis of the promoter element 2 of paramyxo- and filoviruses, Microbiology Spectrum, in press.
  2. Takagi Y., Sudo K., Yamaguchi S., Urata S., Ohno T., Hirose S., Matsumoto K., Kuramoto T., Serikawa T., Yasuda J., Ikutani M., Nakae S., Characterization of novel, severely immunodeficient PrkdcΔex57/Δex57 mice. Biochem. Biophys. Res. Commun. Vol. 678, 193-199, 2023.
  3. Urata S.*, Yoshikawa R., and Yasuda J.*, Calcium influx regulates the replication of several negative-strand RNA viruses including Severe fever with thrombocytopenia syndrome virus, J. Virol., vol.97 (3), e0001523, 2023.
  4. Urata S.*, Yamaguchi S., Nambu A., Sudo K., Nakae S., Yasuda J.*, The roles of BST-2 in murine B cell development and on virus propagation. Microbiol Immunol., vol.67(3), 105-113, 2023.
  5. Urata S.*, Takouda J., Watanabe Y., Sakaguchi M., Sakurai Y., Inahashi Y., Iwatsuki M., Yasuda J., Tanaka Y., Takeda K., Identification of Surfactin as an anti-Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) multiget compound extracted from the culture broth of marine microbes. Front. Virol., vol.2, 1064265, 2023.
  6. Afowowe T.O., Sakurai Y., Urata S., Zadeh V.R., Yasuda J., Topoisomerase II as a Novel Antiviral Target against Panarenaviral Diseases. Viruses, vol.15 (1): 105, 2022.
  7. Zadeh V.R., Afowowe T.O., Abe H., Urata S., Yasuda J., Potential and mechanism of favipiravir as an antiviral against Junin virus. PLoS Pathog., vol.18 (7): e1010689, 2022.
  8. Hirano M., Sakurai Y., Urata S., Kurosaki Y., Yasuda J., Yoshii K., A screen of FDA-approved drugs with minigenome identified tigecycline as an antiviral targeting nucleoprotein of Crimean-Congo hemorrhagic fever virus. Antiviral Res., vol.200, 105276, 2022.
  9. Urata S.*, Omotuyi O.I., Izumisawa A., Ishikawa T., Mizuta S., Sakurai Y., Mizutani T., Ueda H., Tanaka Y., Yasuda J.*, Identification of novel chemical compounds targeting filovirus VP40-mediated particle production, Antivirus Res., vol.199, 105267, 2022.
  10. Takenaga T., Zhang Z., Muramoto Y., Fehling S.K., Hirabayashi A., Takamatsu Y., Kajikawa J., Miyamoto S., Nakano M., Urata S., Groseth A., Strecker T., Noda T., CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor., Viruses, vol.13 (9), 1763, 2021.
  11. Ngwe Tun M.M., Morita K., Ishikawa T*., Urata S.*, The antiviral effect of the chemical compounds targeting DED/EDh motifs of the viral proteins on Lymphocytic Choriomeningitis virus and SARS-CoV-2, Viruses , vol.13 (7), 1220, 2021.
  12. Raini S.K., Takamatsu Y., Dumre S.P., Urata S., Mizukami S., Moi M.L., Hayasaki D., Inoue S., Morita K., Ngwe Tun M.M., The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection, Antiviral Res., vol.192, 105121, 2021.
  13. Urata S.*, Yasuda J., Iwasaki M., Loperamide inhibits replication of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses, vol.13 (5), 869, 2021.
  14. Ushijima Y, Abe H, Ozeki T, Ondo GN, Mbadinga MJVM, Bikangui R, Nze-Nkogue C, Akomo-Okoue EF, Ella GWE, Koumba LBM, Nso BCBB, Mintsa-Nguema R, Makouloutou-Nzassi P, Makanga BK, Nguelet FLM, Zadeh VR, Urata S., Mbouna AVN, Massinga-Loembe M, Agnandji ST, Lell B, Yasuda J., Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa., Int J Infect Dis., 105:452-459, 2021.
  15. Mizutani T.*, Ohba Y., Mizuta S., Yasuda J. and Urata S.*, An antiviral drug screening platform with a FRET biosensor for measurement of arenavirus Z assembly, Cell Structure and Function, vol.45 (2), 155-163, 2020 (*co-corresponding author)
  16. Mpingabo P.I., Urata S., Yasuda J., Analysis of the cell type-dependence on the arenavirus Z-mediated virus-like particle production., Frontiers in Microbiology, vol.11, 562814, 2020.
  17. Zadeh V., Urata S., Sakaguchi M., Yasuda J., Human BST-2/Tetherin inhibits Junin virus release from host cells and its inhibition is partially countracted by viral nucleoprotein., J. Gen Virol., vol.101 (6), 573-586, 2020.
  18. Urata S., Ishikawa T., Yasuda J., Roles of YIGL sequence of Ebola virus, VP40 on genome replication and particle production. J. Gen. Virol., vol. 100 (7), 1099-1111, 2019.
  19. Pemba CM, Kurosaki Y, Yoshikawa R, Oloniniyi OK, Urata S., Sueyoshi M, Zadeh VR, Nwafor I, Iroezindu MO, Ajayi NA, Chukwubike CM, Chika-Igwenyi NM, Ndu AC, Nwidi DU, Maehira Y, Unigwe US, Ojide CK, Onwe EO, Yasuda J., Development of an RT-LAMP assay for the detection of Lassa viruses in southeast and south-central Nigeria., J. Virol. Methods., vol.269: 30-37, 2019.
  20. Yoshikawa R, Sakabe S, Urata S., Yasuda J., Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs., J. Virol., vol.93 (10), e02226-18, 2019.
  21. Oloniniyi O.K., Unigwe U.S., Okada S., Kimura M., Koyano S., Miyazaki Y., Iroezindu M.O., Ajayi N.A., Chukwubike C.M., Chika-Igwenyi N.M., Ndu A.C., Nwidi D.U., Abe H., Urata S., Kurosaki Y., Yasuda J., Genetic characterization of Lassa virus strains isolated from 2012 to 2016 in southeastern Nigeria. PLoS Negl Trop Dis. vol 12 (11), e0006971, 2018.
  22. Urata S.*, Kenyon E.*, Nayak D., Cubbit B., Kurosaki Y., Yasuda J., de la Torre, JC., McGavern DB., BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection. (*Equal contribution) PLoS Pathogens. Vol.14 (7), e1007172, 2018.
  23. Urata S., Uno Y., Kurosaki Y., Yasuda J., The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus. Biochem. Biophys. Res. Commun. Vol.503, 631-636, 2018.
  24. Watanabe K., Ishikawa T., Otaki H., Mizuta S., Hamada T., Nakagaki T., Ishibashi D., Urata S., Yasuda J., Tanaka Y., Nishida N., Structure-based drug discovery for combating influenza virus by targeting the PA-PB1 interaction. Sci. Rep. 7(1):9500, 2017
  25. Uchida L., Urata S.,Uldanday G.E.L., Takamatsu Y., Yasuda J., Morita K., Hayasaka D., Suppressive effects of the site 1 protease (S1P) inhibitor, PF-429242, on Dengue virus propagation, Viruses, vol. 8 (2), E46, 2016
  26. Urata S., Weyer J., Storm N., Miyazaki Y., van Vuren PJ., Paweska JT., Yasuda J., Analysis of assembly and budding of Lujo virus, J. Virol., Vol.90 (6), 3257-61, 2016
  27. Urata S., Yasuda J., Cis- and cell type dependent trans-requirements for Lassa virus-like particle production, J Gen Virol. vol.96, 1626-1635, 2015
  28. Iwasaki M., Urata S., Cho Y., Ngo N., de la Torre J.C. Cell Entry of Lymphocytic Choriomeningitis Virus Is Restricted In Myotubes. Virology vol.458-459, 22-32, 2014
  29. Urata S., Ngo N., de la Torre JC., The PI3K/Akt Pathway Contributes To Arenavirus Budding. J. Virol. vol.86 (8): 4578-85, 2012
  30. Fukuma A., Abe M., Urata S., Yoshikawa R., Morikawa Y., Miyazawa T., Yasuda J., Viral and cellular requirements for the budding of the Feline Endogenous Retrovirus RD-114. Virol. J., vol. 8, 540, 2011
  31. Popkin DL., Teijaro JR., Sullivan BM., Urata S., Rutschmann S., de la Torre JC., Kunz S., Beutler B., Oldstone M.. Hypomorphic mutation in the site-1 protease mbtps1 endows resistance to persistent viral infection in a cell-specific manner. Cell Host Microbe. vol.9 (3): 212-22, 2011
  32. Urata S., Yun N., Pasquato A., Paessler S., Kunz S., de la Torre JC.. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J. Virol. vol.85 (2): 795-803, 2011
  33. Urata S., Yasuda J.. Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40. J. Gen. Virol. vol. 91: 228-34, 2010
  34. Urata S., Yasuda J., de la Torre JC.. The z protein of the new world arenavirus tacaribe virus has bona fide budding activity that does not dependent on known late domain motifs. J. Virol. vol.83 (23): 12651-5, 2009
  35. Sakuma T., Noda T., Urata S., Kawaoka Y., Yasuda J.. Inhibition of Lassa and Marburg virus production by tetherin. J. Virol. vol. 83 (5): 2382-5, 2009
  36. Urata S., Yokosawa H., Yasuda J.. Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix. Virol. J. vol.4, 66, 2007
  37. Urata S., Noda T., Kawaoka Y., Morikawa S., Yokosawa H., Yasuda J.. Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP. J. Virol. vol.81 (9): 4895-9, 2007
  38. Urata S., Noda T., Kawaoka Y., Yokosawa H., Yasuda J.. Cellular factors required for Lassa virus budding. J. Virol. vol. 80 (8): 4191-5, 2006

総説論文

  1. 南保　明日香、浦田　秀造、津田　祥美、長崎大学BSL-4施設使用に係る教育訓練プログラム開発への取り組み、ウイルス、第72巻第2号、p.125-130、2022年
  2. 李　明恩、駒　貴明、岩崎　正治、浦田　秀造、南米出血熱ウイルスとその感染予防・治療法の最前線、ウイルス、第72巻第1号、p.7-18、2022年
  3. 泉澤 文子、水谷 龍明、浦田　秀造、ラッサウイルス・エボラウイルスに対する創薬研究、生体と科学、Vol.72、No.4、p326-329、2021年
  4. 浦田　秀造、「げっ歯類媒介性のアレナウイルス感染症 (ラッサ熱を含む)」、人と動物の共通感染症研究会ニュースレター
  5. 浦田　秀造、抗アレナウイルスおよび抗フィロウイルス薬シーズの開発と現状、最新医学、第74巻・第4号、p93-101、2019年
  6. Tani H. and Urata S., Arenavirus research and antiviral candidate, Uirusu, vol. 68 (2), 51-62, 2018
  7. Urata S. and Yasuda J., Molecular mechanism of arenavirus budding. Viruses vol. 4 (10), 2049-2079, 2012
  8. Urata S., de la Torre JC., Arenavirus budding. Adv. Virol. 2011, Article ID 180326
  9. Emonet SE*., Urata S*., de la Torre JC*.. Arenavirus reverse genetics: New approaches for the investigation of arenavirus biology and development of antiviral strategies. (* Equal contribution) Virology vol.411 (2): 416-25, 2011

受賞

  1. 2019年度日本ウイルス学会杉浦奨励賞受賞「高病原性ウイルスの増殖機構の解明及びその創薬への応用」
  2. 第39回角尾学術賞「新興高病原性ウイルスの細胞内複製機構解析及びその抗ウイルス療法への応用」
    高度感染症研究センターHP: https://www.ccpid.nagasaki-u.ac.jp/浦田秀造%e3%80%80准教授が第３９回「角尾学術賞」を受/
    医学部医学科HP: https://www.med.nagasaki-u.ac.jp/med/contents/02_tsunoo.html